Hsps and aging
نویسندگان
چکیده
منابع مشابه
Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity
Extracellular heat-shock proteins (HSPs) interact with the immune system in a very complex manner. Many such HSPs exert powerful effects on the immune response, playing both stimulatory and regulatory roles. However, the influence of the HSPs on immunity appears to be positive or negative in nature - rarely neutral. Thus, the HSPs can act as dominant antigens and can comprise key components of ...
متن کاملHDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
متن کاملEctothermy and endothermy: evolutionary perspectives of thermoprotection by HSPs.
Living organisms respond to heat exposure by selectively expressing heat shock proteins (HSPs). Accumulation of HSPs confers thermotolerance in cell cultures and in ectotherms and is an important component of the heat shock response. This response, however, has not been directly examined in relation to different ;thermal states', namely ectothermy vs endothermy. By using avian development as a ...
متن کاملEditorial: HSPs—Ambiguous Mediators of Immunity
Specialty section: This article was submitted to Vaccines and Molecular Therapeutics, a section of the journal Frontiers in Immunology Editorial on the Research Topic HSPs—Ambiguous Mediators of Immunity Heat shock proteins (HSPs) were discovered as polypeptides induced by stress that can be found in all kingdoms of cellular organisms. Their functions were, a first enigmatic and these proteins ...
متن کاملHeat Shock Proteins (HSPs): a Review
Heat shock proteins (HSPs) are a large class of proteins that have been conserved throughout evolution and exist by prokaryote and eukaryote organisms. Heat shock proteins play an important role in protein homeostasis. They can found in all major cellular compartments. The HSP90 family are important in the formation of the steroid receptor complex. The HSP70 family is necessary for protein synt...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2009
ISSN: 1043-2760
DOI: 10.1016/j.tem.2008.12.005